Engineer, Process Development

Job Description

Job Description

The Company

Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease.

Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines.

The company's initial three programs VERVE-101, VERVE-102, and VERVE-201 target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease.

VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy.

VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia.

In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.

The Position

As an Engineer, gRNA Process Development, you will play an integral role in a team responsible for development of RNA manufacturing processes for Verve's novel gene editing therapies.

The ideal candidate will have experience with nucleic acid process development technology, including both synthesis and downstream processing of oligonucleotide drug substance.

In this highly collaborative and cross-functional role, you will have both lab and office responsibilities coordinating time-sensitive activities across numerous areas of gRNA drug substance development.

Job Responsibilities

• Contribute to RNA process development initiatives focused on improving product quality, definition of scalable process parameter ranges, and reducing cost of goods.
• Operate, troubleshoot, and maintain oligonucleotide synthesizers (AKTA OP100 and Oligosynt), HPLCs, AKTA Avants (and other FPLC equipment).
• Draft and maintain Standard Operating Procedures, GLP batch records, safety SOPs, and lab / experimental notebooks.
• Support RNA production, process / equipment troubleshooting, and training of team members.
• Partner closely with members of facilities, lab operations, and safety to maintain safety standards within the lab.
• Collaborate with cross-functional teams to facilitate progress of process development projects.
• Participate in vendor interactions focused on process development and manufacturing.
• Other duties as assigned.

Qualifications

• B.S. with 2-5 years or M.S. with 1-3 years of experience or equivalent in biological sciences, chemistry, or biomedical / chemical engineering
• Knowledge of practices and equipment to run oligonucleotide manufacturing processes in a GLP environment, including solid phase synthesis, cleavage and deprotection, chromatography, TFF, sterile filtration, single-use technology, and sterile / aseptic processing preferred
• Highly communicative and detail-oriented approach to working in cross-functional teams
• Attention to detail, critical analysis of data / reports, and troubleshooting abilities
• Proven ability to achieve results, communicate effectively, and find solutions as needed to ensure that project deliverables are met
• Knowledge of oligonucleotide drug substance production and / or manufacture (preferred)
• Proven ability to maintain lab safety standards

Don't check off every box in the requirements listed above? Please consider applying anyway. We want the best candidates for the job, and those candidates don't always meet 100% of the qualifications listed.

At Verve, we are dedicated to building diverse and inclusive teams who embody the values we share : grit, spirit, drive, and passion.

We look forward to learning more about your unique background.

EEO Statement

Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

If you have a disability or special need that requires accommodation, please let us know.

Recruitment & Staffing Agencies

Verve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location;

Verve Therapeutics is not responsible for any fees related to unsolicited resumes.