Pioneering Medicines | Cambridge, MA Pioneering Medicines: Executive Director, In Vivo Pharmacology

Cambridge, MA USA

Scroll down to find an indepth overview of this job, and what is expected of candidates Make an application by clicking on the Apply button.

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need.

Unique to Pioneering Medicines’ approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments.

About Flagship Pioneering :

Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability.

Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.

Position Summary :

Pioneering Medicines is currently seeking an experienced leader with deep expertise in drug discovery and development to head our In Vivo Pharmacology team.

The ideal candidate has strong experience in testing a wide range of therapeutic modalities and disease areas in preclinical species, including but not limited to metabolism, oncology, and inflammation.

A clear track record of successfully leading teams in the execution of PK / PD and efficacy studies is required. The successful candidate will be an enthusiastic, goal-driven individual who is willing to roll up their sleeves and participate as a strategic leader as well as foster a culture of executional excellence.

Key responsibilities of this role include growing and developing the existing team, communicating across functions within PM and with external partners including Flagship companies and pharmaceutical partners, and driving in vivo strategy of programs across the portfolio.

Key Responsibilities :

• Lead, manage and mentor the in vivo Pharmacology team.
• Ensure leadership and oversight for development and implementation of in vivo preclinical efficacy, safety and PK / PD studies as well as ex vivo assays to support pharmacology studies.
• Hands-on contributions to the design, direction, execution, and analysis of pharmacological studies to advance candidates along the developmental pipeline.
• Develop scientific and technical strategy to advance multiple projects in the pipeline.
• Integrate data to provide a detailed understanding of the pharmacology of therapeutic proteins to enable understanding of in vitro MOAs and in vivo correlates of efficacy.
• Identify, initiate, and manage productive collaborations with CROs and academic labs as appropriate to driving projects forward.
• Proactively recognize and develop creative solutions for emerging technical and scientific issues.
• Explore biomarker hypotheses using pre-clinical animal models.
• Maintain scientific and technical expertise through familiarity with scientific literature.
• Contribute to building a positive, team-oriented culture.

Qualifications :

• PhD in pharmacology or biological disciplines such as immunology, cellular biology, oncology, or biochemistry, with 10+ years direct pharmaceutical experience beyond postdoctoral work.
• Experience in at least two of the following disease areas : immunology / inflammation, obesity, cardiovascular or oncology.
• Deep pharmacology experience, particularly on the design of PK / PD studies.
• A track record in driving projects along the developmental pipeline.
• Ability to manage multiple projects and balance a broad set of priorities.
• Demonstrated ability to lead teams to drive go / no go decisions.
• Excellent project management skills and the ability to effectively manage CROs and to facilitate interactions with academic labs and companies to ensure project progression.
• Direct experience in supporting IND strategy and documentation, including writing relevant pharmacology sections of INDs.
• Flexibility to dynamically adapt workplans and lead teams through changing priorities and deadlines.
• Ability to work both independently and collaboratively in a team-oriented, dynamic environment.
• Excellent oral and written communication skills across all levels.
• Prior experience working in smaller companies is highly preferred.

J-18808-Ljbffr