Job Description
General Summary :
Our Seattle site is seeking a talented and motivated Protein Engineer (Senior Scientist) to join our dynamic team. If you are passionate about advancing scientific research and developing novel therapeutics, this role is for you!
Key Duties and Responsibilities :
- Design and execute protein engineering / directed evolution campaigns to improve binding affinity, stability, and selectivity.
- Utilize yeast surface display technology for library screening and directed evolution.
- Drawing from a deep array of Rosetta scripts and machine learning tools, create computational design strategies to deliver protein drug candidates.
- Effectively communicate design strategies to interdisciplinary team members.
- Collaborate with cross-functional teams to optimize protein candidates for function, manufacturability, and immunogenicity.
- Prepare reports, papers, and patent applications, collaborating closely with inventors, scientists, and legal counsel.
Knowledge and Skills :
- Strong understanding of the biophysics of protein structure / function relationships
- Proven experience in directed evolution, yeast surface display, and protein engineering.
- Demonstrated proficiency in protein modeling and design utilizing Rosetta software suite, Alphafold2, ColabFold, Protein MPNN, RFdiffusion or equivalent tools for insilico protein engineering
- Strong analytical skills and attention to detail
- Excellent communication and teamwork abilities
- Familiarity with antibody engineering and affinity maturation
- Experience in cellular assay development
- Understanding of cell biology and immunology
Education and Experience :
- Ph.D. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 2-5 years of relevant post-doctoral, industry employment experience, or
- M.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 5+ years of relevant industry employment experience, or
- B.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 8+ years of relevant industry employment experience
This position will be based out of our Seattle site location focused on protein engineering for the organization. Over the past 9 years we have utilized protein engineering to create a robust pipeline including Acazicolcept (ALPN-101) and Povetacicept (ALPN-303)
Senior Protein Engineer Scientist
Our Seattle site is seeking a talented and motivated Protein Engineer (Senior Scientist) to join our dynamic team. Demonstrated proficiency in protein modeling and design utilizing Rosetta software suite, Alphafold2, ColabFold, Protein MPNN, RFdiffusion or equivalent tools for insilico protein engin...
Senior Applied Scientist (Research Software Development Engineer)
Within Azure Data, the big data analytics team providesa range of products that enable data engineersanddata scientiststo extract intelligence from all data–structured, semi-structured, and unstructured. In particular, we are hiring a Senior Applied Scientist for the Gray Systems Lab (GSL), an appli...
Senior Scientist, Geoscientist or Engineer for Emergency Response Team
Geologist, Engineer, or Scientist to work with our Superfund Technical Assessment and Response Team (START) performing EPA Investigations, Removal Assessments, and Removal candidate will work withintheSTARTteam providing ourEPA client with accurate and pertinent scientific data according toagreedup...
Research Scientist/engineer - Senior
The Research Scientist/Engineer- Senior provides direct oversight and coordination of complex research protocols for multiple federally funded research projects coordinated across multiple clinical sites as well as administrative and operations for the multidisciplinary research group, the UW Clinic...
Senior Safety Scientist or Engineer for Emergency Response Team
Geologist, Engineer, or Scientist with Safety experienceto work with our Superfund Technical Assessment and Response Team (START) performing EPA Emergency Responses, Investigations, Removal Assessments, and Removal candidate will perform in a seniorleadership role withintheSTARTteam providing ourEP...
Senior Staff Data Scientist
Staff Data Scientist - Marketplace Algorithms. ...
Senior Data Scientist - 2202145
Were seeking a Senior Data Scientist to join our team and play a crucial role in generating insights and supporting data-driven decision-making across the organization. Job Title: Senior Data Scientist. Develop data pipelines to ensure data quality and availability for analysis. Experience as a data...
Data Analyst - Maple Valley, WA | Onsite
The Data Analyst will report directly to the Director of Finance and Accounting, while playing a key role in supporting the entire organization. The analyst will be responsible for gathering, analyzing, and interpreting complex data sets to provide actionable insights that enhance operational effici...
Engineering - Data Science - Research Scientist
Job Title: Research Scientist. As a Research Scientist at Read, your contributions will directly impact how we leverage the latest advances in machine learning and generative models, to make our users smarter. This hands-on research and development position requires not only your quantitat...
User Research Assistant
We require a User Research Assistant on our team to handle logistics for our research studies, including recruiting, scheduling, rewarding participants, maintaining lab equipment, installing and preparing study devices and software, annotating and recording participant sessions, editing videos, and ...