Senior Principal Scientist/Associate Director, Radioligand Modeling & Simulation
Senior Principal Scientist / Associate Director, Radioligand Modeling & Simulation
Job ID : REQ-10019029
Please ensure you read the below overview and requirements for this employment opportunity completely.
Date : Sep 03, 2024
Location : Cambridge, MA (No remote work available)
Summary
We are seeking an experienced translational or clinical modeler eager to accelerate radioligand discovery & development by enabling rigorous decision making with modeling & simulation.
You will work in a multi-disciplinary environment, with opportunities to engage in and / or lead cross-functional initiatives.
This role reports to a PK Sciences Translational Modeling team lead, in a group situated within Biomedical Research, the research engine of Novartis.
Key Responsibilities
- Act as the Translational M&S representative on radioligand therapy programs, developing and executing modeling strategies, contributing to project team discussions, and guiding therapeutic design and dose selection decisions.
- Build and apply innovative QSP and physiologically based PK (PBPK) models along with dosimetry estimations to link RLT pharmacology, tissue biodistribution, mechanism(s) of action, and biological and clinical outcomes.
- Advance the development of an integrated RLT modeling platform that bridges data and knowledge across preclinical species and patients, partnering with discovery project teams as well as the preclinical safety and pharmacometrics groups.
- Advance the translational science for radiopharmaceuticals, setting new standards in how to guide RLT discovery and clinical development.
- Proactively seek opportunities to increase the impact and awareness of translational and clinical modeling through communications with internal and external audiences.
- Contribute to group strategy and serve as an M&S subject area expert across PK Sciences and Biomedical Research initiatives.
- Ph.D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field with 6+ years of experience (experience in industry preferred) as well as demonstrated mastery of radiobiology / nuclear medicine.
- Extensive experience, preferably in industry, in pharmacokinetics and pharmacodynamics (PK / PD), quantitative systems pharmacology (QSP), and / or physiologically based PK (PBPK) modeling is required.
- Expert level proficiency in core modeling fundamentals is required, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization.
Proficiency in dosimetry is a plus.
- Demonstrated ability to communicate modeling results to a multidisciplinary audience to facilitate decision-making.
- Demonstrated ability to independently develop and implement modeling strategy across a disease area and / or modality platform.
- Demonstrated scientific leadership in Modeling & Simulation and ability to effectively partner with and influence the broader drug discovery and development organization to be considered at the Associate Director level.
- Fluent in English (oral and written).
This is a dual level posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered.
Benefits and Rewards
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Commitment to Diversity and Inclusion
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
Compensation and Benefits Summary
The pay range for this position at commencement of employment is expected to be between $166,400 - $249,600 / year; however, while salary ranges are effective from 1 / 1 / 24 through 12 / 31 / 24, fluctuations in the job market may necessitate adjustments to pay ranges during this period.
Why Novartis
Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you.
Ready to create a brighter future together? Learn more.
Accessibility & Reasonable Accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities.
If you need a reasonable accommodation for any part of the application process, please send an e-mail to us.reasonableaccommodations@novartis.
com or call +1(877)395-2339.
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