Senior Associate Scientist

This role is considered On-Site.

Overview

The successful candidate will be a part of the Process Science group, responsible for process development, in-house non-GMP manufacturing, report and protocol authoring and reviewing, process transfer to CMOs, and stage 1 manufacturing process validation for siRNA oligonucleotides.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Oligonucleotide manufacturing, process development, optimization, and scale up in a cGLP environment.
• Operation of process scale instrumentation.
• Operation of analytical instruments and application of analytical techniques including LC-MS and UV-Vis.
• SOPs and manufacturing documents drafting / reviewing according to regulatory and procedural guidelines.

Qualifications

• BS in Chemical Engineering or Chemistry with a minimum of 2 years lab experience, preferably in an industrial setting.
• Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.). Related hands-on experience is preferred.

Knowledge of oligonucleotide manufacture process including phosphoramidite chemistry, chromatography, ultrafiltration etc. is a plus.

Experience in record-keeping and excellent laboratory documentation practice, are required. Strong commitment to high laboratory and scientific standard.

About Alnylam : Alnylam Pharmaceuticals (Nasdaq : ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases.

Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease.

Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture : Our people-first culture is guided by our core values : fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make.

Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential.

By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.

Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.