Senior Scientist, Bioconjugation

Senior Scientist, Bioconjugation

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Gaithersburg, MD

Are you ready to take our leading Oncology pipeline to the next level? As a Senior Scientist in Bioconjugation, you will play a pivotal role in advancing the development of cutting-edge antibody drug conjugates across various therapeutic domains.

We are seeking a driven and proficient Senior Scientist, Bioconjugation with a strong foundation in drug discovery. This role offers an exciting opportunity to spearhead and contribute to multifaceted drug development endeavors.

Typical Accountabilities :

As a Senior Scientist, you will execute conjugation, purification, and characterization of ADCs, ranging from milligram to gram quantities, utilizing a variety of established methodologies.

You will innovate and optimize novel conjugation techniques to enhance ADC properties and coordinate and streamline conjugation workflows within a collaborative team environment.

You will also engage in cross-functional collaboration with diverse scientific teams spanning therapeutic areas, chemistry, and process development to drive research progress and foster technological breakthroughs.

Leading and overseeing laboratory operations, including equipment maintenance and adherence to safety protocols, will also be part of your responsibilities.

Essential Skills / Experience :

PhD in Organic Chemistry, Chemical Biology, Biochemistry, or related field with a minimum of 2 years of relevant experience;

OR Master's degree in Organic Chemistry, Chemical Biology, Biochemistry, or related field with at least 7 years of relevant experience.

• Extensive hands-on expertise in designing and generating antibody drug conjugates.
• Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC.
• Hands-on experience in protein purification using HIC, IEX, SEC, and affinity chromatography, preferably with GE AKTA FPLC.
• Consistent record of working autonomously, adeptly planning and organizing tasks, and prioritizing activities to meet project deadlines.
• Demonstrated skill in protocol optimization and troubleshooting with a problem-solving approach, along with meticulous record-keeping in laboratory notebooks.
• Track record of scientific innovation showcased through publications, patents, and presentations at scientific conferences.
• Exceptional written and verbal communication skills, with the ability to convey complex scientific data effectively to cross-functional teams and senior management.

Desirable Skills / Experience :

• Experience in protein engineering and production would be advantageous.
• Familiarity with coordinating activities with Contract Research Organizations (CROs).

Closing Date : November 1, 2024

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.

We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.

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