Senior Scientist - Early Oncology

At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality.

We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new insights to life.

AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death.

We are seeking a highly motivated and independent Senior Scientist with experience in radiopharmaceutical development to join our radioconjugate (RC) portfolio team within the Early Oncology Discovery group in Gaithersburg, MD USA.

Requisites for this role include a proven track record of scientific excellence and several years of project leadership experience.

As a Senior Scientist in our group, you will be the tumorbiology lead for emerging RC portfolio projects,working both with our internal project teams andwith external partners to develop novel targeted alpha therapies.

As a core project lead, you willuseyour theoretical and practical expertise todeliver pre-clinical datasets,synthesizecross-functional findings,establish program priorities, and advance the project through all stages of pre-clinical will represent the project team in front of governance committees and will present program updates at other internal forums.

In addition to your individual project leadership responsibilities, you will alsoprovide intellectual contributions and cross-functional support to RC teams acrossthe portfolio.

Main Duties and Responsibilities

You will be expected to serve as the tumor biology lead for one or more radioconjugate programs, working collaboratively with internal cross-functional teams and external partners to ensure the timely generation and dissemination of critical program data to enable project milestone decisions.

As a highly organized, self-motivated individual with a strong background incancer research and radiobiology, you will stay up to date with relevant technical, intellectual, and scientific expertise in tumor biology and cancer modelling, particularly as it relates to targeted radioconjugates, and have a genuine passion for this field of research.

Essential Requirements

PhD Degree with 0-3+ years of experience, Master’s Degree with 5+ years of experience, or a Bachelor’s Degree with 7+ years and project leadership experience in a relevant field related to tumor and radiation biology.

Expertise in targeted radiopharmaceutical therapies, with broad knowledge of the field, is required for consideration of the candidate.

Demonstrated ability to lead cross functional project teams.

Solid understanding of radiation biology, cell biology, and / or biochemistry in the context of cancer, with a robust desire for continued learning.

Experience with routine cell culture, particularly culture of tumor cells

Expertise in molecular- and cell-based methodologies, such as cloning / gene editing, cytotoxicity assays, binding and internalization assays, flow cytometry, ELISA, and Western blotting

Works independently with minimal supervision to conduct experiments, analyze data, and prepare results for internal and external presentations and regulatory filings

Excellent communication, presentation, and interpersonal skills evidencedby a history of successful projectdelivery in team-oriented, collaborative environments.

A proven track record of efficiency, as demonstrated by scientific publications in high quality peer-reviewed journals.

Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal AstraZeneca standards and external regulations.

Desirable Requirements

Prior experience in the biopharmaceutical industry and familiarity managing data delivery through contract research organizationspreferable but not required.

Demonstrated ability to coordinate project activities and provide scientific mentorship to junior scientists is highly preferred.

Direct, hands-on experience in residualization & saturation binding assays, PET-CT imaging, biodistribution studies, non-clinical dosimetry, and other pre-clinical radioimmunoconjugate methods is highly desirable.

Experience with targeted alpha emitter therapeutics would be considered favorably.

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Date Posted

17-Apr-2024

Closing Date

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process.

We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments / accommodations to help all candidates to perform at their best.

If you have a need for any adjustments / accommodations, please complete the section in the application form.AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.