Job Description
AbbVie is recruiting for a Sr. Scientist I / II, Drug Substance Purification Process Development position in the Department of Neurotoxin & Biologics Process Sciences (NBPS), at its Irvine, CA site.
Position Description :
The Sr. Scientist I / II, Drug Substance Purification Process Development, will be an instrumental team member of the NBPS group.
The primary roles of this position are to lead drug substance downstream process development and optimization studies for natural and recombinant proteins (including neurotoxins) from bacterial cultures during discovery and process development.
The desired candidate will have a solid understanding and hands-on work experience with all aspects of biologics downstream process development, including protein purification / characterization, process chromatography, tangential flow filtration, depth filtration operations, and preferably with some analytical skills such as SDS-PAGE, western blot, mass spectrometry, and dynamic light scattering.
The successful candidate will perform laboratory work, develop productive collaborations and communications with other groups across scientific disciplines and be motivated to innovate and succeed in a fast-paced, collaborative environment.
Key Responsibilities :
Lead research and development studies, author research protocols / reports and present findings in the multidisciplinary team environment.
Perform and support process development / mapping, protein structure / function and solution behavior evaluation, design and execution of experiments for downstream drug substance manufacturing process.
Demonstrate significant level of hands-on experience and in-depth knowledge in protein purification, protein analysis, downstream processes development, process optimization, and design and execution of the studies.
The role requires evaluating new technologies relevant to protein purification, protein analysis, process chromatography, tangential flow filtration, depth filtration operations to enhance process understanding.
Work closely with members of process development and other functional groups such as analytical development, drug discovery, science & technology, and manufacturing in creating a collaborative environment for advancement of robust manufacturing processes.
Represent the department and participate in cross-functional project teams to promote innovative ideas and advance pipelines.
Display leadership skills that result in good performance and career development of junior staff and possess excellent communication (oral and written) and interpersonal skills.
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