At AstraZeneca, we win through science, it’s at the heart of our every success. That science is only possible when we all work together we’ll always make sure you’re clear about how your role is connected to our wider mission to really show what science can do!
We are seekinga to join Integrated Bioanalysis organization to support Non-GXP bioanalysis and pharmacokinetic / toxicokinetic assessments by LC-MS for critical projects within AstraZeneca portfolio.
Your primary responsibilities will include :
Apply state-of-the-art mass spectrometry instrumentation to address sophisticated bioanalytical challenges related to drug discovery and development
Development, validation / qualification of LC-MS assays in support of pharmacokinetic (PK), toxicokinetic (TK), Biomarker Quantification in variety of biological matrices
Sample analysis for exploratory, GLP and clinical studies using automated and manual sample extraction platforms
Perform data analysis on acquired datasets, collaborate with pharmacologists, statisticians, data scientists across global AstraZeneca teams
Serve as bioanalytical expert on multidisciplinary project teams
Adhere to established Standard Operating Procedures, industry practice and regulatory guidance as appropriate
Contribute to validation / qualification protocols and reports, bioanalytical reports, clinical study reports, etc., as appropriate
Demonstrate competency in troubleshooting, optimization and implementation of challenging and innovative LC-MS / MS assays
Essential Requirements :
For Associate Director :
PhD in Chemistry, Biochemistry, Pharmaceutical Sciences or related scientific field
7-10 years of postdoctoral and industry experience
Background in analytical (bio)chemistry with emphasis on mass spectrometry applications in at least one of the following : PK of biologics (ADCs or Proteins), biomarker quantification, characterization and relative quantification for impurities / protein PTM
Hands-on experience with chromatographic separation, characterization and quantification of various analytes by LCMS.
Familiarity with triple quadrupole mass spectrometry instruments, experience with high resolution (HRMS, ToF or Orbitrap) is a plus;
Proficiency with mass spectrometry software, data analysis software (Spotfire, R, MATLAB, JMP, etc.) word processing, and graphical computer programs
Excellent organizational, documentation and technical writing skills
Excellent command of English (written and oral)
Strong communication and interpersonal skills
The ability to perform in a fast-paced, matrix-structured work environment.
Strong publication / presentation record in analytical (bio)chemistry, bioanalysis, metabolomics / proteomics, or biomarker discovery
Significant experience in method development, troubleshooting and complex bioanalytical methods
Solid understanding of regulatory guidance on bioanalysis with GxP studies, white papers and industry standards for bioanalysis
Experience serving as functional representative on multidisciplinary project teams with demonstrated ability to communicate complex data effectively to diverse audiences
Experience managing / mentoring / supervising junior staff
Pharmaceutical / biotech Industry experience
Desirable Requirements
Pharmaceutical / biotech Industry experience
Familiarity with chromatographic assay validation guidelines, GLP / GXP regulations and fit-for-purpose validation principles
Experience working in GLP-like / GLP / GMP settings
Hands on experience with Sciex MS systems
Hands on experience with reverse phase liquid chromatography (RPLC)
Experience with protein labelling / LBA assay / magnetic bead basedpurification
Experience with automated / semi-automated sample preparation
Protein / ADC / macromolecule mass spectrometry experience
Experience in bioanalysis / characterization of antibody-drug conjugates
Benefits :
AstraZeneca is a leading company in the healthcare industry, with a mission to enrich the lives of others. It’s our business to support healthy living, not only for our patients, but also for our employees.
Our benefits program is flexible enough to meet employees’ varying needs, offers valuable choices, and is highly competitive.
Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big.
Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential.
Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be.
This means we’re opening new ways to work, pioneering cutting edgemethods and bringing unexpected teams together.
Come and join our journey - Apply today!
Where can I find out more?
Our Social Media, Follow AstraZeneca on LinkedIn
Follow AstraZeneca on Facebook
Follow AstraZeneca on Instagram
Date Posted
25-Jun-2024
Closing Date
08-Jul-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process.
We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments / accommodations to help all candidates to perform at their best.
If you have a need for any adjustments / accommodations, please complete the section in the application form.AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
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