Scientist I, Biologics Drug Substance Development, Cell Culture Development

Job Description

DESCRIPTION :

The Cell Culture Development Group in South San Francisco, CA is seeking a Scientist I to join a talented and collaborative team to develop cell culture processes for GMP applications.

In this position, you will perform cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies.

KEY RESPONSIBILITIES :

• Design and execute robust and scalable cell culture processes in ambr250, 2L, 50L, 200L 500L single use bioreactors
• Design scalable inoculum expansion and master cell bank generation processes
• Design and execute small scale and pilot scale depth filtration and centrifugation primary recovery processes
• Participate in the tech transfer of Master cell bank generation, cell culture and primary recovery processes to the GMP manufacturing facilities in Worcester, MA
• Provide person-in-plant support at the GMP manufacturing facility
• Represent the cell culture development group in cross-functional meetings and collaborate closely with cell line, purification, analytical and formulation development leads to meet project timelines
• Author and review technical reports, GMP campaign summary reports and relevant sections in regulatory filings
• Actively seek out opportunities to optimize our platform or enhance our understanding of cell culture processes
• Contribute to publishing or presenting scientific findings in in-house or external conferences
• Display effective organization, verbal written communication skills, and adherence to good documentation practices

Qualifications

• Scientific degree in chemical engineering, bioengineering, biotechnology, or a related field, 2 years for M.S., or 5 years for B.S.
• Proficient in aseptic techniques
• Experienced in developing and executing mammalian suspension cell culture processes in shake flasks, ambr250 and 2L bioreactors
• Experience with perfusion technology, especially Alternating Tangential flow filtration (ATF)
• Strong understanding of mammalian cell and molecular biology and cell culture bioprocess engineering concepts
• Strong attention to detail; active and quick learner; able to change course quickly as needed, raises the bar and is never satisfied with the status quo;

open to suggestions and embraces the ideas of others; collaborative actively builds relationships with others

• Experienced in technical report authoring and reviewing
• Proficient with Microsoft Office software (Word, Excel, and Powerpoint) and statistical modelling software (JMP, SIMCA, Minitab, Design Expert)

Preferred :

• Experience with programming (VBA, Python, Javascript, C++)
• Experience with authoring peer-reviewed publications, technical reports, regulatory documents, and / or presentations at conferences
• Have a strong understanding of statistical analysis and design of experiments (DOE)

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law :

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position.

Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range.

This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical / dental / vision insurance and 401(k) to eligible employees.

This job is eligible to participate in our short-term incentive programs.

Note : No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.

It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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