Key Responsibilities and Activities Design, develop, and execute cell-based bioassays to evaluate performance of investigative drugs (biologics) Stay updated with cutting edge discoveries and trends and contribute to the company’s R&D strategy to generate and test actionable development plans Identify emerging methods, tools, and biology approaches, and implement them when applicable Function as a key team member, and simultaneously train and supervise associates on the R&D team Collaborate closely with other scientists and research associates on the R&D team Contribute to work with external parties, including academic collaborators and CROs to create comprehensive capabilities for MoA, target validation and potency studies Write clear and concise research reports and ensure study documentation and update protocols to ELN Participate and contribute to internal discussions and meetings Present results to the project leadership team and management in an organized and timely manner Required Education, Experience, Skills and Competencies Ph.
D. in Cellular Biology, Immunology, or a relevant discipline At least 2 years of industry research experience Extensive experience working with different types of in vitro systems such as immune cells, epithelial cells, fibroblasts, endothelial cells, and other cell lines Strong background with cell-based assays to interrogate immune pathway activation, immune suppression, cytotoxicity, antibody mediated cell killing Broad skillset for target validation, potency evaluation and MoA interrogations is highly desired, including the use of tissue culture approach with multiple readouts, flow cytometry, ex-vivo studies, use of gene knockdown tools, conventional immunoassays, phosphorylation analysis and conventional pulldown assays.
Hands on ability to execute wet lab experiments, data processing, and ability to effectively communicate key scientific findings across the organization Ability to establish and maintain cooperative working relationships with co-workers and other stakeholders Ability to adjust to workload changes and prioritize competing demands Ability to balance the big picture and fine technical details Outstanding organizational, critical thinking, and problem-solving skills Excellent written and verbal communication skills Powered by JazzHR
Research Senior Scientist, Antibody Discovery & Engineering, In Vivo Based Methods
You will include deep scientific engagement and involvement in programs; defining the best path forward based on the therapeutic needs, designing immunization strategies, performing immunizations/animal handling and tissue harvest, and conducting HT antibody discovery using technologies using single...
Senior Scientist, Genomics in Stem Cell Sciences Group
We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic informa...
Senior Research Associate, In Vivo Pharmacology/bioanalytics
Backed by Fapon Biotech, an international leader in in vitro diagnostics, biologics, and precision medicines, the RNA Venture is an innovative Lexington-based biotechnology startup building the RNA medicines of tomorrow. Are you a skilled RNA analytical scientist with a passion for cutting-edge tech...
Senior Research Associate, in vivo Pharmacology/Bioanalytics
Backed by Fapon Biotech, an international leader in in vitro diagnostics, biologics, and precision medicines, the RNA Venture is an innovative Lexington-based biotechnology startup building the RNA medicines of tomorrow. Are you a skilled RNA analytical scientist with a passion for cutting-edge tech...
Scientist/Sr. Scientist – In Vivo Pharmacology
The in vivo pharmacology Scientist/Senior Scientist/Principal Scientist will participate in the Gene Therapy. Perform rodent handling and dosing, including but not limited to subcutaneous (SC), intravenous (IV), intraperitoneal (IP), and intrathecal (IT) injections. Experience in processing, organiz...
Scientist - Senior Scientist, in vivo Research CRISPR-X
Opportunities in this role include designing our translational in vivo research strategy to evaluate next-gen editing technologies, ensuring appropriate resourcing for, and execution of, all preclinical in vivo studies and reports within the CRISPR-X research team, authoring preclinical content for ...
Scientist/Sr. Scientist – In Vivo Pharmacology
The in vivo pharmacology Scientist/Senior Scientist/Principal Scientist will participate in the Gene Therapy. Perform rodent handling and dosing, including but not limited to subcutaneous (SC), intravenous (IV), intraperitoneal (IP), and intrathecal (IT) injections. Experience in processing, organiz...
Research Scientist, In Vivo Pharmacology
You will have experience in inflammatory disease, fibrotic and extra-cellular matrix pathobiology, innate and adaptive cell biology and associated in vivo models of disease to join the Gastro-Intestinal Inflammation Research (Drug Discovery Unit). You will possess strong technical skills and primari...
Scientist - Senior Scientist, in vivo Research CRISPR-X
Opportunities in this role include designing our translational in vivo research strategy to evaluate next-gen editing technologies, ensuring appropriate resourcing for, and execution of, all preclinical in vivo studies and reports within the CRISPR-X research team, authoring preclinical content for ...
Principal Scientist or Assoc. Dir. of T cell in vivo Pharmacology
We are seeking an in vivo Pharmacology Principal Scientist/Associate Director to join our Preclinical Efficacy and Safety group to contribute to advancing Adaptimmune’s early preclinical pipeline toward clinical evaluation. Further, you will be an ad hoc contributing collaborator to our in vitro imm...