Postdoctoral Researcher – Cardiovascular Gene Editing/Delivery

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases.

We are pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs.

With five currently marketed medicines for serious diseases and an expansive late-stage pipeline, we continue to build upon our groundbreaking innovations in science and technology to provide greater value to patients;

and we are well positioned financially to deliver on our strategic goals.

If you are interested in applying for this job, please make sure you meet the following requirements as listed below.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence.

We know our success is a direct result of the exceptional talent and dedication of our employees.

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team.

We continue to invest time, money, and energy into making our onsite and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.

We are building on our rich history, and believe our greatest achievements are ahead of us. We invite you to apply and join us if you’re passionate about the opportunity to have meaningful impact on patients in need, our employees, and our organization.

Experience and contribute to our unique culture while you develop and expand your career!

POSTDOCTORAL RESEARCHER - CARDIOVASCULAR GENE EDITING / DELIVERY

SUMMARY :

We are seeking an enthusiastic postdoctoral scientist interested in using CRISPR gene editing to address root causes of heart failure and arrhythmia to join the Cardiovascular Drug Discovery group, a multi-disciplinary team of energetic researchers.

The successful candidate will work in a matrix group environment to explore in vivo gene editing for cardiovascular diseases.

He / She will work independently to conceptualize, design and execute experiments using rodent and human cell models. Background in RNA, molecular biology, and CRISPR / Cas systems are essential for the position.

Experience in cardiovascular biology and drug delivery is a plus.

RESPONSIBILITIES :

• Design, execute and troubleshoot experiments relevant to the postdoctoral project.
• Formulate solutions for delivery of therapeutics in vitro and in vivo and contribute to optimization.
• Measure and analyze pharmacodynamic and functional effects of treatments in rodent and cell models of disease.
• Present results at internal and external scientific meetings.
• Prepare manuscript for publication.

REQUIREMENTS :

• Ph.D. in molecular biology, biochemistry, or related fields with 0-3 years of postgraduate training.
• Strong laboratory skills in molecular biology and biochemical assays, e.g. RNA and protein isolation, RT-qPCR, ELISA, Western Blotting.
• Proficiency in rodent handling, dosing (IV, SC, IM) and necropsy.
• Hands-on experience with CRISPR / Cas systems.
• Excellent written and verbal communication skills.
• Required to be full-time onsite at Carlsbad, CA.

PREFERRED SKILLS :

• Experience with in vivo imaging systems (IVIS) is desirable.
• Exposure to non-viral vector in vivo delivery desirable.
• Experience with lipid formulation for in vivo and in vitro delivery.
• Experience with cardiomyocyte culture (primary and / or iPSC-CMs).
• Exposure to cardiac functional assessments, including echocardiography.
• Experience with confocal microscopy.

Please visit our website, http : / / www.ionis.com , for more information about Ionis and to apply for this position; reference requisition #IONIS003471.

Ionis offers an excellent benefits package! Follow this link for more details : Ionis Benefits

Full Benefits Link : https : / / www.ionis.com / careers / working-at-ionis / # : : text to Applicants -,Benefits,-Employees are rewarded

The pay scale for this position is $78,000 to $87,000.

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

LI-Onsite

J-18808-Ljbffr