Executive Director, Computational Systems Biology

Overview

Executive Director and Head of Research Computational Biology at Revolution Medicines. The role oversees the scientific and strategic direction of systems biology research and preclinical computational biology initiatives within the Biology Function, leading a team of computational biologists and bioinformaticians to analyze large multi-omics data sets to inform treatment strategies and patient stratification for a growing pipeline of RAS(ON) and targeted oncology therapeutics.

Responsibilities

• Strategic vision and leadership : Develop and implement a long-term strategy for research systems biology and bioinformatic activities to support a growing pipeline of RAS(ON) and novel targeted inhibitors. Lead and supervise a team to generate, organize, and interpret large data sets to inform therapeutic and combination strategies for cancer patients.
• Cross-functional collaboration : Work across research, translational, development, and medical affairs to advance programs from discovery to clinical development using insights from computational approaches. Leverage clinical data from RVMD investigational agents to generate proprietary insights into RAS mutant tumor biology and inhibitor mechanisms of action.
• Technical leadership and innovation : Oversee analysis of large, high-dimensional datasets, data integration and visualization on cloud platforms (AWS, Azure, GCP). Guide the development and application of statistical analysis, AI / ML methods, generative AI models, and MLOps to biomarker discovery, drug target identification, and predictive modeling. Establish modern workflow management and reproducible research practices (e.g., Snakemake, Nextflow).
• External collaboration : Cultivate academic and industry partnerships, including CROs. Represent the company at scientific conferences, maintain an active publication record, and drive IP strategy and patent filings related to computational discoveries.

Required Skills, Experience and Education

Base pay salary range for onsite work in Redwood City, CA : $256,000 — $320,000 USD. This range is the base pay and may be adjusted for local market factors. Total rewards also include equity, benefits, and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity / expression, national origin / ancestry, age, disability, marital status, medical condition, and veteran status. We respect your privacy and handle personal data in accordance with our CCPA Notice and Privacy Policy. For more information, contact privacy@revmed.com.

Job Details

Note : This posting may include location-specific listings and related opportunities; focus here on the Executive Director, Head of Research Computational Biology role and its requirements.

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